Endocrine Abstracts

Oral administration of chloroquine (CHQ) evokes adverse effects on glucose homeostasis and kidney function possibly due to transiently high plasma CHQ concentration or malaria. We have, however, reported that transdermally administered CHQ via the pectin CHQ-matrix patch formulation sustains controlled CHQ release into the bloodstream in experimental animals. Accordingly, the current study was designed to compare the ability of oral and transdermal CHQ treatments to clear para...

The tight glycaemic control in type 1 diabetes which requires uncomfortable multiple insulin injections is associated with patients’ non-compliance. Therefore, methods which can sustain therapeutic controlled insulin release into the blood based on topical applications may be beneficial with glycaemic control. Accordingly, the present study investigated whether topically applied pectin insulin (PI) amidated matrix patch sustains insulin release into the bloodstream and co...

The magnitude and duration of postprandial blood glucose elevations due to hydrolysis of carbohydrates are major risk factors of diabetes and coronary heart diseases. Inhibition of the key carbohydrate hydrolyzing enzymes in the small intestine suppresses postprandial blood glucose peaks and reduces chronic vascular complications in diabetic subjects. Recent reports indicate that Syzygium spp-derived oleanolic acid (OA) inhibits glucose transport in the small intestin...